Kara and Lena track Lex to Kaznia, and find Eve but no Lex. Ben abandons his son to go after his wife's killer, which pits him against Brainiac-5, Dreamer, and the newly superpowered James. Alex and Kelly travel to meet with a woman giving birth to a child who could become Alex's.

Lex's plan reaches fruition: Red Daughter has defeated Supergirl, Lex has defeated the Kaznians and then Red Daughter. Now only one thing can stop him: the power of the Fourth Estate.