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Lex's plan reaches fruition: Red Daughter has defeated Supergirl, Lex has defeated the Kaznians and then Red Daughter. Now only one thing can stop him: the power of the Fourth Estate.
Supergirl and Alex go after Red Daughter, while Lena and James hunt down Ben. Brainiac-5, J'onn, and Dreamer attempt to rescue the alien prisoners, but two of them are captured and one of them is "rebooted".