A group of mortals calling themselves the Hunters--and who know who and what the Immortals are--come gunning for them, starting with Darius.

Grace Chandel has been a Good Immortal, working for the betterment of mankind as a midwife, doctor, and scientist over the centuries. Her one weakness is another Immortal, Carlo Sendaro, a former lover who is obsessed with her and refuses to let her go. He slays Grace's current (mortal) lover and, when she refuses to run off with him, frames her for the killing. She turns to her old friend Duncan MacLeod for help.

A mysterious death at the Paris Opera re-acquaints Duncan MacLeod with one of the strangest Immortals he has met in his many travels over the centuries. Ursa is a hulking giant -- more beast than man -- who Duncan rescued from persecution centuries ago, delivering him to sanctuary in an abbey. The abbey has long since been destroyed and Ursa now lives under Paris. He has become enamored of a past-her-prime opera singer who tries to use Ursa's innocent soul to murder her rival.

Duncan goes up against an Immortal who uses poison gas to give himself an edge in the battle against other Immortals... and to wipe out any mortals who get in his path.

The immortal Grayson attempts to drive his former mentor Darius out of holy ground by killing Darius' pupils.

After seeing Duncan's miraculous recovery from what should have been a fatal accident, an unethical ER doctor kidnaps the Highlander to study his recuperative powers and determine his secrets.