Bob Fossil has a big problem at the Zoo-niverse. Ivan, the bear has developed some very anti-social habits. The last straw is exposing himself to the visitors. Fossil arranges for a place for Ivan at an Animal Offenders Institute. All Fossil has to do is find a couple of idiots to drive the bear there in the clapped-out old Zoo-Niverse van. All Howard and Vince have to do is get Ivan there, in one piece, without falling foul of the Hitcher.

Vince is convinced David Bowie invented music. According to Vince, Howard's past career as a jazz trumpeter does not measure up. When Vince is offered a chance to join a new band, called Kraftwerk Orange, with Johnny Two Hats and the Electro Girls, he's intent on leaving everything behind, including Howard.

Howard is hellbent on a career as a serious writer. He thinks it will also improve his chances with Mrs Gideon. When a famous publisher, Hamilton Cork, arrives at the Zoo-Niverse, it's Vince's literary efforts, in the shape of Charlie, a pink bubble gum character, which takes Cork's fancy. Meanwhile Bob Fossil has embarked on a new breeding programme for the pandas.

Dixon Bainbridge, owner of the Zoo-Niverse, is intent on selling to the highest bidder. There's a road being built through it and 'if the animals won't work on it, they'll be underneath it.' Howard and Vince embark on an arduous trip deep into the Jungle Room in search of the only man who can help save the zoo - Howard's hero, Tommy Nooka.

In an attempt to compete with daring adventurer, Dixon Bainbridge, Howard and Vince set off in search of the Egg of Mantumbi. Into the whiteness, the nothingness of the arctic tundra, the boys come face to face with hideous ice demon, Black Frost. Luckily, Vince has befriended a polar bear.

Bollo, the oldest and most respected gorilla at the Zoo-niverse, is gravely ill. Bob Fossil persuades Howard to dress in an ape suit, replacing Bollo, so that he can continue accepting sponsorship money for the gorilla. Everything's going smoothly until the Grim Reaper arrives and mistakenly takes Howard to Ape Hell instead. Vince, guided by Naboo, sets off to rescue Howard, and on the way meets Mr Susan, caretaker of the Mirror World. Howard and Vince run into trouble when they encounter the Ape of Death who is plagued by problem hair.

All is not well at the Zoo-niverse. Animals are disappearing one by one. Things go from bad to worse when Joey Moose, one of the zookeepers goes missing. When Mrs Gideon reports that her python is also on the missing list, reported stolen, Howard is determined to save the day. Howard and Vince stumble across Dixon Bainbridge's secret laboratory and the terrible truth behind his 'experiments' comes to light.

A highly illegal boxing match is set up between Killeroo the kangaroo and Howard. Vince enlists the help of his bare-knuckles fighter uncle in order to assist Howard with his training.

Two zookeepers begin a journey through time and space as they search for a prized egg amidst the wastelands of the Arctic tundra.