Neil deGrasse Tyson features his interview with actor Alan Alda and discusses science communication with comedian Matt Kirshen and neuroscientist Heather Berlin. Anthropologist Natalia Reagan joins them later.

Neil deGrasse Tyson interviews Margot Lee Shetterly, author of "Hidden Figures: The American Dream and the Untold Story of the Black Women Mathematicians Who Helped Win the Space Race," and actress Janelle Mone, who starred in the movie. He discusses NASA's hidden figures with comedian Sasheer Zamata and NASA Chief Historian Bill Barry. Tracy Drain, a NASA systems engineer, joins them. Bill Nye, the Science Guy, also appears.