The first season concludes with a psychotic woman accusing the FBI's deputy director of stealing her baby and keeping her forcibly medicated to cover up the crime. No one believes her except Hood.

Four murders occur during Fashion Week in New York City when rage overtakes seemingly ordinary individuals with no prior history of violence. Hood investigates to discover what triggered the homicidal outbursts.

Hood investigates when seemingly unrelated people across Philadelphia simultaneously develop symptoms of toxic exposure.

Hood investigates when 30 people are struck by lightning during a 10-minute thunderstorm.

Hood investigates after a healthy helicopter pilot who flies for a local TV station goes blind during a live traffic report, which results in a deadly crash.

Hood investigates a series of stem-cell thefts that he suspects is part of a cloning operation headed by his nemesis, Gepetto.

Hood is called in to investigate when a millionaire dies and the autopsy reveals two fully developed hearts in the deceased man.

Hood investigates when a boy's cancerous tumor miraculously disappears after he drinks water from a natural spring in Montana. Hood doesn't believe the water is responsible and sets out to prove it.

Hood investigates an epidemic of irrational and violent outbursts among citizens of a once-quiet Texas suburb, and it doesn't take long until Hood succumbs to the same psychotic behavior.

Hood investigates when students on spring break are exposed to deadly flesh-eating bacteria. He must discover its source and find a cure.

Hood travels to Oklahoma to investigate why some college students are dying of the bends, a condition normally associated with scuba divers, and discovers an enormous medical cover-up on campus.

Hood investigates when a government experiment to create supersoldiers goes tragically awry.

Hood investigates when a woman's frozen body is discovered on a hot California beach and shows no signs of thawing. The investigation reveals that the victim had a terminal blood disease, but it had nothing to do with her death. Later, another person with a fatal illness is found frozen in an office building. Hood learns that both victims may be linked to a foundation that promises people immortality.

Hood travels to Pittsburgh, where a lethal virus discovered at a demolition site threatens to spread. He must find a way to contain it before it becomes a deadly epidemic.

Hood investigates when severely autistic teens are kidnapped across the U.S. and then reappear weeks later with symptoms of savant syndrome.

Dr. Jacob Hood, Special Science Advisor to the FBI, is called upon to investigate when multiple cases of food-related paralysis are reported in North California.

Hood and Rachel travel to a small Georgia town to investigate the deaths of three seemingly healthy 11-year-old boys who died of heart attacks. Tension rises among the locals as fear overtakes them and another boy collapses.

Top biophysicist Jacob Hood investigates crimes of a scientific nature for the FBI. In the series opener, evidence is discovered that suggests someone is attempting to clone humans. Nineteen buried fetuses are found near Seattle and the probe reveals they all have the same DNA.