Shio Ogura, a seemingly normal Japanese high school student, who, while visiting Taiwan on a school trip, is suddenly attacked by monsters. Agents known as "E-Gene Holders" from the government agency DOGOO also arrive, who wield weapons infused with the spirits of historical figures. However in the midst of it all, Shio is revealed to also be an E-Gene Holder when the soul of Oda Nobunaga awakens after she tries to rescue a friend.