With the world believing him to be dead, David Banner is on the run, trying to find a way to be cured of his transformations into the Hulk. Meanwhile, David lands a job at a ranch, where he befriends a young heiress. He notices that the woman is being given a questionable drug by her physician. He then overhears a plot to kill her so that her stepmother could gain an inheritance; he also learns that the recent death of the young woman's father was no accident. Now, David must get the heiress to safety before it is too late.

While working at a zoo, David finds a female scientist doing genetic research, which could help him stop his unwanted transformations into the Hulk.