David 'Brown' boards a Boeing 747 plane in San Francisco to travel to Chicago in pursuit of a cure for his metamorphosis. The airline captain and a flight attendant have planned the theft of a priceless Egyptian exhibit from the plane's cargo hold. After dealing with the scheming couple, David is forced to land the plane in Denver during one of his transformations into the Hulk.

In Nevada, a group of hijackers led by Ted and Mike steal a semi-truck from the father of a young woman named Joanie as she makes plans to steal it back. David 'Bradford' becomes mixed up in her plans, and is forced to transform into the Hulk to save both of their lives.