An accidental overdose of gamma radiation creates a mutation in David Banner's DNA: whenever he becomes angry, he metamorphoses into an over seven-foot-tall, 330-pound, mindless muscular green creature. Tabloid newspaper reporter, Jack McGee begins investigating claims of a giant creature: his investigation leads to the laboratory that Banner was using. An explosion in the lab kills Banner's associate and friend Dr. Elaina Marks. McGee, who dubs the creature "the Hulk", believes it killed David too. Unable to explain the truth, nor control his transformations, David leaves to try to find a cure for himself.

Notes: Originally a two-hour movie, is shown in two parts in syndication.