Danny and Baez team up with Danny's old partner, Jackie Curatola, to find a copycat killer emulating a criminal's murders from a previous case; Frank and Mayor Chase battle over how best to handle the city's rising homeless population; and Jamie, Eddie and Erin team up to build evidence against a man previously released, but once again committing criminal assault.

Frank worries about his longtime friend Lenny Ross when he suspects the former officer is hiding his true reason for returning to the city. Also, Danny and Baez investigate when Baez and her daughter are targeted by a criminal Baez once put away; Eddie gives her partner, Badillo, relationship advice when his ex-girlfriend is physically attacked; and Anthony is sucked into the inner workings of an underground crime ring when his chaotic cousin, Joey, begs him for a favor.

Jamie partners with the FDNY to find the arsonist responsible for a massive fire at an NYPD evidence storage facility. Also, Danny and Baez feel the ripples of the storage facility fire when all the evidence against a cartel leader Danny brought to justice is destroyed; Anthony asks Erin to let him lead on a murder case when his friend is killed; and Eddie asks Frank to put her on modified duty following her divisive arrest of an anti-cop protestor at a rally

Danny and Baez investigate a case of grand larceny tied to feuding crime families when the gifts are stolen during a mob wedding. Also, Frank clashes with Mayor Chase when an influx of immigrants arrive in the city; Erin questions whether her district attorney campaign is compromising her day job; and Eddie enlists Jamie's help to bust a drug dealer responsible for fentanyl overdoses in order to comfort a grieving grandfather.

Frank clashes with the Dream Team when one of the members becomes the focus of a departmental investigation. Also, Jamie and Danny team up to investigate a series of carjackings involving one of Danny's criminal informants; Eddie and her partner, Badillo, help a woman being stalked by a man she met on a dating app; and Erin is determined to find the culprit behind online attacks on her boss, district attorney Crawford.

Jamie and Eddie find themselves at odds when Jamie learns that Eddie's close friend Tracey may be using the restaurant she owns as a drug front. Also, Erin forms an alliance with Anthony and her ex-husband, Jack Boyle, when she is accused of causing the suicide of a former colleague; Frank weighs whether he should fire a female officer who has an online profile featuring naked photos of herself; and Danny and Baez try not to be influenced by their own biases when they are faced with various descriptions of the same suspect.

Danny partners with Texas Ranger Waylon Gates again to deliver an infamous drug cartel boss to arraignment, but the mission becomes complicated when the criminal threatens to harm the Reagans. Also, Erin is thrust into the spotlight when she takes on a highly contentious assault case involving a beloved basketball star; Eddie forms an unlikely alliance to solve a cold murder case; and Frank and Jamie clash when Frank denies a request for Jamie to go undercover.

The return of Rachel Witten, Eddie's former partner turned social worker, tests her loyalties and conflicts Frank, when Rachel brings an accusation of excessive force against an officer. Also, Danny and Baez clash with a troubled foster child at the center of their latest investigation and Erin must make a tough decision about her campaign run for district attorney.

Danny and Baez race against the clock to catch a serial killer targeting young women across the city. Also, Erin and Eddie clash when Eddie intervenes in a murder case and Erin's personal life; and Frank must decide how to discipline his grandson Joe Hill when Joe breaks protocol while working on a joint task force with the FBI.

Danny reunites with Mickey Patrick, his childhood friend and a former criminal, who comes to him for help finding his missing fiancée. Also, Anthony surprises Erin with one last stakeout before her run for district attorney; Jamie helps a former officer caught committing a crime with the purpose of helping others; and Frank comes face to face with a woman who confesses to killing her husband.

Danny and Baez's investigation into the death of a chess hustler is complicated by interference from the victim's son; Jamie tries to make amends with a man he regrets putting away as a young officer.

Jamie and his new intel team officer infiltrate a high-tech car smuggling ring. Also, Frank faces off against the city's transit chief over a new mayoral solo police patrol program that is causing officer injuries on the job; Eddie asks Danny to help her bust a cop impersonator; and Erin hires an image consultant to help with her D.A. campaign.

Reagan family tensions run high when Frank and his grandson, Joe Hill, contend with a grievous insult to the memory of Joe's father, Joe Reagan. Also, Erin and Henry work together to bust an over-the-phone scammer targeting the elderly; Danny intervenes in an undercover assignment led by his spiraling former partner; and Eddie's captain takes suspicious interest in her efforts to locate a stolen puppy.

Danny crosses paths with Sonny Le, a criminal from a previous case, when he investigates a gang attack with a shocking motive. Also, Frank and Mayor Chase butt heads over an off-duty cop who goes too far making a political statement; Anthony worries Erin's DA campaign could be threatened by her ex-husband Jack's unsavory business connections; and Jamie investigates a potentially dirty officer whose identity may be close to home.

Erin and Anthony clash when Anthony's daughter, Sophia, is the sole eyewitness to a fatal shooting. Also, Frank wants to punish an off-duty cop for his inaction during an armed robbery; Danny and Baez investigate a violent mugging with some unwanted help from Jamie; and Eddie and her partner, Badillo, help an attack victim see the brighter side of New York City.

Danny and Jamie clash over a gang-related shooting after Jamie oversteps as part of his new position and Danny empathizes too closely with a victim. Also, Erin and Anthony search for answers when a lawyer in their office jeopardizes a case involving Erin's nephew, Joe Hill; and Frank grows concerned when he's not invited to speak at a policing forum.

Frank launches an investigation after the Reagan family is harassed when protests against a controversial NYPD unit escalate. Also, Danny and Baez form an unlikely partnership with an informant in order to prevent a murder; Eddie lands in hot water after she defies a direct order; and conflict arises between Erin and the Dream Team when the D.A.'s office strikes a deal with Baker's assailant.

Danny and Baez investigate a series of violent robberies targeting luxury timepieces, and Erin is conflicted about criminally charging a potentially innocent man. Also, Frank is forced to reopen a case in which the officer involved was acquitted, and Jamie interviews a decorated officer to join his Field Intel team.

Danny and Baez investigate after a vicious attack leaves their mutual friend, Maggie Gibson, hospitalized. Also, Frank and the Dream Team debate the appropriate memorial protocol for a former police commissioner with a questionable professional legacy; Jamie begs Erin to release a perp who can lead him to a powerful criminal; and Eddie's car is vandalized by her partner Badillo's ex-girlfriend.

Frank causes family tension when he announces he will not endorse Erin's run for district attorney. Also, Danny and Baez investigate a bloody crime scene at a hotel, and Jamie begins a new job as a field intelligence sergeant that requires him to keep secrets from his family.

The job takes a dangerous turn for the Reagans when Eddie and Jamie deal with a domestic violence case associated with an investigation led by Danny and Baez. Also, Frank and his friend, Archbishop Kearns, go on a mission to avail themselves to an unfiltered look at the city; and Erin is presented with a surprising offer by her ex-husband, Jack Boyle, regarding her run for District Attorney.