Mysterious Personal Shopper tells the story of the love, friendship and betrayal between two women: Hong Se Yun and Eun Kyung Hye.

Hong Se Yun works as a personal shopper. She is outgoing and a positive person, but she is betrayed by people whom she loved. She begins to take revenge on those who betrayed her. Meanwhile, Eun Kyung Hye is the only child of a CEO. Her life looks perfect, but she has a fear that she will get abandoned. Because of her fear, she has an impulse control disorder and gets compulsive.