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Neal clashes with his neurosurgeon father over how to treat his gravely ill mother, whose mysterious symptoms force Angels Memorial to quarantine Trauma One.
A new surgical attending Cole Guthrie joins Angels Memorial with the help of his estranged father and clashes with Leanne over their contrasting approaches to medicine. Also, Christa has a crisis of confidence in the middle of a procedure on her first infant since the loss of her son.
Leanne struggles with whether to treat a police officer who helped her during an accident or his shooter, who has more serious injuries. Meanwhile, Malaya's pregnant ex-girlfriend arrives at the hospital with pain in her arm, and Malaya is shocked by her MRI results.