Neal clashes with his neurosurgeon father over how to treat his gravely ill mother, whose mysterious symptoms force Angels Memorial to quarantine Trauma One.

Angus uses his background in psychology to help a woman who doesn't remember how she injured herself and others. Also, when Christa bonds with an illegal immigrant whose son is diagnosed with cystic fibrosis, she becomes determined to help the woman find long-term care for her son in the U.S.