At the centre of Plastic Beauty is Fumi Numata, a gifted surgeon whose passion lies in saving lives through medicine. When circumstances push her to shift from general surgery to aesthetics, she finds herself at odds with Rin Tohyama, a celebrity cosmetic surgeon who views beauty as a form of salvation. Through their clash and the stories of patients caught in the pursuit of physical perfection, the series unravels the emotional, psychological, and societal pressures behind the beauty boom.