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El Chapo reflects on his childhood and how he entered the drug business. His punishments in prison become more severe.
Violence surrounds Gen. Blanco. El Chapo tries to acclimate to life in prison but gets a rude awakening when he tries to bribe a guard.
Don Sol continues to work his way up the political ladder and interrogates El Chapo, who offers him information in exchange for a deal.
Don Sol feeds information to Gabriela as she looks for a victim to go on the record against Gen. Blanco. Chapo meets with a drug lord in Guatemala.
The government offers a reward for the capture of El Chapo, and he is forced to go into hiding while making plans to flee the country.
Ramón brings in a group of sicarios in a hunt for El Chapo. A mass shooting at an airport arouses suspicion and a prominent cardinal dies.
The Mexican government recruits Amado to help control the escalating violence. The Avendaño brothers cross a line.
Chapo desires to achieve patron status and feels disrespected as he tries to collaborate with drug lords. Miguel Ángel must make a decision.
El Chapo must fulfill his promise to Pablo Escobar of moving cocaine across the border under a shortened timeline, or pay the price.
Season 2 picks up with Chapo's first prison break and goes on to reveal the critical role corrupt government officials play in aiding El Chapo's rise over his rival cartel bosses. Viewers will also begin to see how his quest to become the leader of the powerful Sinaloa Cartel impacts the lives of those closest to him, including his family.