Lukas has Parry-Romberg Syndrome, causing half his face to shrink inward. Stefani's rare muscular dystrophy leaves her dependent on her mother but craving independence. Ellie says steroid withdrawal left her with lizard skin and seeks a cure.

There are only two foods that won't send Caroline into anaphylaxis; touching almost anything causes Ariana's butterfly skin to blister and tear; Aleazia's cystic hygroma caused his jaw and tongue to swell, permanently freezing his mouth open.