An allergic reaction left Kirtus with vitiligo, alopecia, and bone loss. An upcoming surgery could change his life. Portia's rare skin condition may exist in fewer than 25 people worldwide. Dani lost all four limbs, and now she fights to walk unassisted.

Zahra is housebound by a rare condition, but new prosthetics may be her ticket to freedom. Mahogany's leg weighs nearly 100 pounds due to lymphedema. Joseph was born without a jaw but won't let it stop him.