Dr. Jeff fights to save a bearded dragon suffering from massive seizures; Dr. Nichols must learn why a dog has lost its appetite and has difficulty breathing; a routine cat neuter gets intense quickly.

Dr. Jeff races to save the legs of a puppy who has been hit by a car while newly hired exotic pet vet, Dr. Baier, treats a Burmese python. Then with Dr. Jeff recovering from knee surgery, the team comes face to face with a pride of lions.