After 26 years, Dr. Jeff and the team move to a brand new clinic with double the space; Melodie worries her dad isn't resting after chemo treatment; Dr. Jeff makes a special connection with the owner of a dog, when repairing the dog's knee.

Dr. Jeff tries his best to suppress news that he has a serious medical issue as he performs complex surgery on an internally bleeding puppy; the team races to fix a young dog's badly broken leg after a car hits it.

Doctor Jeff performs knee surgery on a dog; three sugar gliders have an attitude problem; the mobile clinic heads to South Dakota to help animals on a Native American reservation.

When two Chihuahuas are found abandoned in a storm drain, Dr. Jeff and his team will do whatever it takes to help them. Then Dr. Jeff makes a surprising discovery when a cat's bizarre eating habits put her life in danger.

A kitten that has suffered head trauma needs immediate attention; Dr. Amy performs a risky surgery on a dog with a very weak heart; family's pit bull is hit by car; two wallabies exhaust Dr. Baier.

With thousands of animals in need, and vet care unaffordable to most, Dr. Jeff and his team head to Mexico to run a mobile clinic and help as many people and pets as they can.

Dr. Jeff races to save the legs of a puppy who has been hit by a car while newly hired exotic pet vet, Dr. Baier, treats a Burmese python. Then with Dr. Jeff recovering from knee surgery, the team comes face to face with a pride of lions.

A young dog suffers a broken leg after jumping out the back of a pick-up truck; a cat gets injured fighting its neighbor's dog; Dr. Jeff helps a rescued fox from the Rockies; rushing to save the pet hedgehog of a fourth-grade class.

Dr. Jeff fights to save a bearded dragon suffering from massive seizures; Dr. Nichols must learn why a dog has lost its appetite and has difficulty breathing; a routine cat neuter gets intense quickly.

Dr. Jeff treats a puppy with a broken leg saved from a kill shelter in Oklahoma; a dog fights for its life after eating an entire box of marijuana-infused chocolates; two abandoned kittens are dropped off; the newest vet helps a rat.

Dr. Jeff and his team must act fast to save the life of a young dog frothing at the mouth; Dr. Lindsay treats a sick goldendoodle; the team treks to the mountains to assist huskies; Penelope the Pig causes Dr. Jeff to try a new surgery.

Dr. Jeff battles to save a beloved dog whose leg has been shattered by a car; Dr. Amy attempts to treat seven ill-tempered chickens; the entire staff pulls together to save a baby kitten found unconscious at a construction site.