Dr. Jeff races to save the legs of a puppy who has been hit by a car while newly hired exotic pet vet, Dr. Baier, treats a Burmese python. Then with Dr. Jeff recovering from knee surgery, the team comes face to face with a pride of lions.

A kitten that has suffered head trauma needs immediate attention; Dr. Amy performs a risky surgery on a dog with a very weak heart; family's pit bull is hit by car; two wallabies exhaust Dr. Baier.