Dr. Jeff treats a skittish Savannah cat with an unusual condition; Dr. Amy helps a beloved dog who was injured chasing a coyote; the team tries to find the owners of a dog rescued on the highway.

Dr. Jeff and Hector help 40 miniature Australian shepherds rescued from a puppy mill; Vet tech Christine turns to Dr. Jeff when her elderly Chihuahua has trouble walking; Dr. Jeff is called out to treat an alpaca with a serious infection.