A mother commits suicide, but there is no sign of her son; four members of an ex-girlfriend's family are murdered allegedly by her ex-boyfriend.

Lori Mejia was a fighter from birth, surviving against the odds and thriving until a downward spiral led her to a deadly encounter with a man named Herberto Maldonado,  also known as "Vampire".  A life-long friend with a dangerous secret, Bruce Sawhill is accused of molesting his best friend's 10-year-old daughter and then fled from law enforcement - setting in motion a tragic chain-reaction of events that would lead to the victim's death by suffocation.

Man is hired by a woman to beat her estranged husband to death; serial molester kidnaps two women with a knife in Oregon.

After being convicted of sexually abusing many children of his constituents in Texas, the leader of a religious Hindu community disappears.

A young mother takes her two-year-old daughter and disappears; serial child molester is apprehended in Texas, but evades his trial and starts his horrific pattern again.

An escaped kidnap victim leads police to a house where two brothers have made a horrifying hobby of kidnapping and torturing prostitutes.

For 15 years, a serially abusing stepfather has been sexually molesting his stepdaughter; nine-year-old girl is being secretly molested by a young, good-looking police officer.

An oppressive, overbearing father is accused of murdering his high school-age daughters when they start dating boys their own age against his wishes.

John Walsh gives an update on all of the Season 1 cases; fugitives still at large, fugitives captured; closed cases.