Two best friends and comic book fanboys, Kaz and Oliver, discover a doorway leading to top-secret hospital called "Mighty Med," where they realize that all their favorite superheroes are real! There, they meet Skylar Storm, a teen hero who recently lost her powers, Horace Diaz, the hospital's Chief of Staff, and Alan Diaz, Horace's meddling nephew with telekinesis powers. When Kaz's all-time favorite superhero Tecton is rushed into the hospital, the boys must use their comic books knowledge to find a way to save Tecton before his nemesis Megahertz finds him first.

Kaz boldly asks the most popular girl in school to the upcoming school carnival but is rejected, and tries to save face by claiming he already has a girlfriend. Much to Oliver's chagrin, Kaz invites Skylar to accompany him to the carnival, her first venture into the "normo" world, in hopes of convincing everyone that she is his girlfriend. Meanwhile, Alan tries to prove his worth to his uncle Horace by attempting to cure Titanio, a superhero with amnesia.