Kaz and Oliver find Skylar's powers, but The Annilator tries to stop them from escaping.

It's been a year since Skylar lost her powers, so Oliver and Kaz decide to throw her a party to celebrate their one-year anniversary of friendship. But when they learn that Skylar is in danger of losing her powers permanently, Oliver and Kaz set out to get them back.

Horace introduces the boys to an all-powerful device that looks like a pen, but can bring any illustration to life. Panic ensues at the hospital when the device goes missing.

Oliver and Skylar pet sit Horace's shark that is kept in the aquatic wing of the hospital. When Oliver feeds the shark the wrong food, the shark evolves into a man-shark.

When Horace complains that comic book sales are down, Oliver and Kaz join the writing staff to help spice up the books. However, the boys' altered versions of the stories cause problems in the superhero community.

Kaz searches for a flash drive, thinking it contains Oliver's study guide for a test, but it turns out to be a digital jail storing a villain named Wi-Fi. When Kaz plugs the drive into his laptop, Wi-Fi enters the physical world and simultaneously pulls Kaz into the computer.

When a freak accident suddenly gives edgy rock star Jade super powers, Oliver and Kaz take her under their wings and introduce her to the world of Mighty Med.

Wallace uses an optical image replicator to turn Clyde into an identical look-alike of Kaz in hopes that the disguised Clyde will trick Oliver into revealing the secret location of Mighty Med.

Kaz launches a superhero fantasy league at the hospital. The heroes become obsessed with their fantasy stats and only perform saves and defeats that will boost their standings in the league. Minnesota Vikings' running back Adrian Peterson guest stars as himself.

Tension is high at Logan high, and Kaz becomes suspicious that his substitute teacher is actually Dr. Wrath in disguise, a supervillain who feeds on negative energy. While Kaz is determined to get to the bottom of it, Oliver helps Alan get over his aversion to normo food.

Kaz and Oliver are exhausted and stuck working the overnight shift during a lunar eclipse, when it is rumored that the freakiest patients come to the hospital. When Neocortex checks in with an illness that unintentionally traps people in their worst nightmares, Kaz and Oliver desperately try to stay awake and figure out how to save everyone from their nightmares.

Oliver accidentally steps into the line of fire of a superhero's beam during a routine test, which reverts him back to being 4 years old. While Kaz tries to fix Oliver, Alan develops an undesirable and embarrassing power.

Kaz and Oliver revive a frozen-in-time superhero from the 1950s named Captain Atomic. After Captain Atomic is wounded during a battle with a contemporary villain, the boys must travel back in time to save him.

Skylar introduces Kaz and Oliver to her longtime friend Experion, a cool and charming teenage superhero. But when Oliver catches Experion in an evil act, he must convince Skylar that her bestie is not as nice as he seems.

Oliver enlists a mind-altering superhero named Neocortex to help him become more carefree and spontaneous like Kaz. When the brainwashed Oliver is too reckless during a crisis, Kaz is forced to step up and be the responsible one.

Kaz plans a surprise birthday party for Oliver at The Domain, but there is a security lockdown at Mighty Med just as they attempt to leave. Convinced that it's a false alarm, Kaz persuades Oliver to sneak out, but accidentally lets in the villain Revengeance. Patton Oswalt ("The King of Queens") guest stars as Ed, a former villain, who Wallace enlists to help stage an intervention to get Clyde to give up his evil ways.

Kaz applies to be Tecton's sidekick, but when Oliver displays an act of heroism, Tecton selects Oliver for the job instead. Meanwhile, Alan and Benny form a superhero team of their own.

Horace leaves for a medical conference and empowers Alan by putting him in charge of the hospital for a day. Alan instantly abuses his powers making life miserable for everyone, especially Oliver and Skylar.

When Gus contracts a strange illness, he develops formidable powers and turns evil. Kaz and Oliver devise a plan to sneak him into the ER for treatment, where they must figure out a way to cure their maniacal friend before he destroys everything in the hospital. Meanwhile, Horace pretends to be Skylar's father for her parent-teacher conference but gets overly carried away with the idea.

When Kaz and Oliver meet Timeline, a superhero who has the ability to see into the future, they discover that villain Crimson Demon and his three brothers have a plan to destroy the world.

Kaz and Oliver learn that pranks do not exist in the world of their superhero friend Skylar, and they set out to teach her how to prank. When The Great Defender joins in, he takes the pranks too far and wreaks havoc on the hospital. Guest starring is NBA star Dwight Howard as The Great Defender.

Oliver uses his burgeoning medical skills at school when he performs CPR on a popular girl's poodle, which quickly elevates his social status much to Kaz's chagrin. When the popularity goes to his head, Kaz cuts Oliver down to size, literally, with a shrinking ray. Meanwhile, Horace cannot perform surgery on Citadel, an ailing superhero with an impenetrable metal exoskeleton, so shrunken Oliver is sent inside the hero's body to diagnose the problem.

Kaz boldly asks the most popular girl in school to the upcoming school carnival but is rejected, and tries to save face by claiming he already has a girlfriend. Much to Oliver's chagrin, Kaz invites Skylar to accompany him to the carnival, her first venture into the "normo" world, in hopes of convincing everyone that she is his girlfriend. Meanwhile, Alan tries to prove his worth to his uncle Horace by attempting to cure Titanio, a superhero with amnesia.

Sworn to secrecy about his mighty discovery, Oliver must follow through with creating a Frankenstein-inspired play when his dad inquires where he goes every day after school. Meanwhile, Kaz and Skylar embark on a mission to uncover the mystery behind the disappearance of the superhero Brain Matter.

Two best friends and comic book fanboys, Kaz and Oliver, discover a doorway leading to top-secret hospital called "Mighty Med," where they realize that all their favorite superheroes are real! There, they meet Skylar Storm, a teen hero who recently lost her powers, Horace Diaz, the hospital's Chief of Staff, and Alan Diaz, Horace's meddling nephew with telekinesis powers. When Kaz's all-time favorite superhero Tecton is rushed into the hospital, the boys must use their comic books knowledge to find a way to save Tecton before his nemesis Megahertz finds him first.

Two best friends and comic book fanboys, Kaz and Oliver, discover a doorway leading to top-secret hospital called "Mighty Med," where they realize that all their favorite superheroes are real! There, they meet Skylar Storm, a teen hero who recently lost her powers, Horace Diaz, the hospital's Chief of Staff, and Alan Diaz, Horace's meddling nephew with telekinesis powers. When Kaz's all-time favorite superhero Tecton is rushed into the hospital, the boys must use their comic books knowledge to find a way to save Tecton before his nemesis Megahertz finds him first.