Kaz and Oliver are exhausted and stuck working the overnight shift during a lunar eclipse, when it is rumored that the freakiest patients come to the hospital. When Neocortex checks in with an illness that unintentionally traps people in their worst nightmares, Kaz and Oliver desperately try to stay awake and figure out how to save everyone from their nightmares.

Kaz launches a superhero fantasy league at the hospital. The heroes become obsessed with their fantasy stats and only perform saves and defeats that will boost their standings in the league. Minnesota Vikings' running back Adrian Peterson guest stars as himself.