Wendell rides Cody 2 around town... and he fornicates with it along the way. Everybody else races to the Annihilatrix while the Deceptacles make a stew out of Watley's decapited body in the motel swimming pool. Finally, Killface's alien brethren (and his mother) arrive to inquire about how the Earth has not yet been annihilated.

Valerie kills Sinn and blames Wendell and Arthur. Xander learns he has an illegitimate daughter. She comes to visit after her mother dies from cancer. Xander bribes her never to contact him again. Wendell decapitates Arthur when he tries to propose to Antagone. Antagone finally gives birth to her monster ant baby, which then eats her head.

Killface and Simon attempt to repair the burnt couplings on the Annihilatrix, while Stan and Taquil attempt an escape from their shot-down plane. Sinn and Val ask Watley to kill Antagone (due to increasing strains on their relationships with Antagone). Meanwhile, Wendell is sent by Xander to kill the giant ant baby. Both Wendell and Watley inadvertently fall in love with Antagone.

The new super-villain team of Sinn, the Dread Lobster, Valerie, and a pregnant Antagone broadcast a message of terror out, using the Annihilatrix to back their claims up. Xander, Killface, and the new President Taqu'il see the message and decide to do something about it...even if there isn't much any of them can do.

While Killface prepares for the Presidential debate, Xander makes a few stops with Ronnie before he arrives at the debate. Both Xander and Killface come to realize that neither of them are qualified or allowed to run for the Presidency due to discrepancies they've both overlooked. Killface decides to follow up on his original plan to destroy the world.

Killface goes over the upcoming debate with Dottie and Wendell looks into alternative campaign funds. Awesome X finds himself a prisoner along with Ronnie on-board Xcalibur.

While Killface recovers from a failed assassination aimed at him, Xander returns as Awesome X in an attempt to get Fred Dyer to be his Vice President. But first he pays a visit to the X-Tacles.

In the aftermath of the latest assassination attempt, Killface finds religion and risks alienating the various groups that have supported him. In the middle of this, he learns a secret about someone very close to him.

Killface and Xander Crews go on a duck hunt in an attempt to promote their public image, but end up getting lost and arguing over movies involving bears.

The Presidential race heats up as Xander Crews reveals his immigration and education plans to the media. Meanwhile, Killface works with his campaign team to figure out a way to ruin Xander's chances of winning the election.

The train wreck that has become Xander Crews' life is filmed for a Killface presidential documentary. This in turn causes Xander to run against him.

A year after Simon started the Annihilatrix, Killface is working on getting elected president. The Annihilatrix did the complete opposite of what Killface intended and pushed the Earth three feet away from the sun, completely ruling out global warming.