Cesar Millan and his son, Andre, travel to San Francisco, California. The duo meet Pali, the founder and president of Rocket Dog Rescue, who canvasses local San Francisco shelters trying to find homes for dogs on the euthanasia list. Pali grew up homeless herself, so she identifies with these dogs that society has forgotten.

Cesar and Andre Millan head to Chicago to meet some local heroes doing great work for man's best friend in the Windy City.