The telenovela tells the story of five women:
-Mariana, sweet and genuine, is poised to marry her surgeon fiancé—who is secretly having an affair with her cousin—but she discovers true love with Camilo.
-Miranda, a tough, resilient, and hardworking woman, hides a traumatic childhood marked by abuse at the hands of her uncle during her teenage years.
-Pamela, a sensual and striking dreamer, knows that to achieve success, she must take on the world and everyone in it.
-Julia, who suffered a devastating blow when she discovered her husband was having an affair with another man, decides to put love behind her for good.
-La Chiqui, who faces the typical relationship struggles that arise when love fades and life becomes a mere routine. 

These women are brought together by their aunt, who faked her own death just to see them, and she convinces them to declare war on the "shameless" men who have caused them all so much suffering.