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Callie and Arizona are at odds over Sofia's future, and Stephanie questions the status of her relationship with Kyle. Meanwhile, Alex and April work on a pregnant teen that is readmitted to Grey Sloan Memorial.
Stephanie struggles with boundaries while Callie and Arizona ask their friends for support during a difficult situation.
Owen and Amelia take their relationship to the next level; Alex gains some clarity on his future with Jo; and Callie and Arizona continue to struggle with the current custody arrangement.
Meredith struggles to deal with all her responsibilities after Amelia moves in with her, while Miranda begins life as the new Chief of Surgery.