During presentations on Grey Sloan Surgical Innovation Prototypes Day, Arizona shares some cookies from an appreciative patient that, unbeknownst to her, contain a special ingredient. Meanwhile, Catherine reveals some shocking details to Jackson about his grandfather's past; and Jo steps in mid-operation on a major surgery after Bailey and Meredith are down for the count.

Alex and Jo go on a road trip to Iowa to find Alex's mom, whom he hasn't heard from in a very long time. Meanwhile, Meredith gives a presentation on her mini-livers project, which attracts a ton of attention; and Jackson works to rebuild the foundation after its reputation is threatens.