On the anniversary of her sister's death, Alex performs heart surgery on a patient who fears she can't leave her personal grief out of the operating room. In other events, Millicent dates a sexy artist; and Pierce wants a bigger role in Alex's family.

When a transgender woman is diagnosed with breast cancer, Alex and Ji-Sung fight to save her life and her identity. Meanwhile, a beautiful consultant from another hospital forces Jesse to confront his feelings for Alex.