Alex and Pierce disagree on whether an experimental treatment for those with advanced stage cancer is right for the hospital's patients. True to form, Alex takes matters into her own hands with a risky move to find volunteers. Meanwhile, Max looks to drastically change the family dynamic with Alex, and Ji-Sung connects with Callahan.

A case brings back memories for Alex, Jesse and Millicent when they try to save a heart transplant patient who sustained devastating injuries in a car crash.