The hospital gets a new administrator, Sy Mittleman, who everyone but the Chief despises. Cat struggles with the loss of Lola, her pregnancy, and her feelings for Nicky. Glenn accidentally discovers the cure for cancer.

Owen wants to have sex with Lola, but he thinks she is a ghost so he asks Dr. Flame to stop his heart to send him to the spirit world to find her. The hospital takes in overflow patients dressed in sexy costumes on Halloween while Chet shows Chief his sexy costume.