In a special live episode, a visiting Sultan needs emergency surgery; Blake faces a crucial decision about his clown make-up; Glenn cuts off his finger for Valerie. A surprise ending reveals the shocking the truth about one of the doctors, shattering everyone's perceptions.

The abortion debate is brought into relief by a visit from a prominent Senator (Ed Begley, Jr.); Owen must decide whether he can treat the 10-year-old who beats him daily; Sy finally faces his alcoholism.

"Take Your Daughter to Work" day at the hospital ignites a series of conflicts involving a leering child molester (Steve Agee), Chief's sexy daughter (Lizzy Caplan), and an 11 year-old patient whose gender is yet to be determined.

Budget problems force a dilemma for Sy, get rid of the coffeemaker which made him popular, or fire a doctor? Glenn faces a battle for Valerie's affection with Rabbi McJewJew.

A power outage during a heat wave wreaks havoc at the hospital, causing staff members to lose their inhibitions. Big Pharma increases the pressure on Glenn to forget about his cancer cure.

Owen organizes a team to save a boy with a knife sticking out of his chest; Glenn is warned to stop trying to cure cancer; a patient with telepathy is asked to help out with hospital business.

An episode of TV news magazine News Readers covering the filming of the final episode of Childrens Hospital, complete with behind the scenes looks at the show. Cutter Spindell (who portrays Blake Downs on the show within the show) interferes to save the series, convincing protesters that they're saving an actual children's hospital.

The hospital accepts an emergency case of two adult men impaled by a pole, but they soon realize they cannot save both and must choose who lives and who dies. In addition, two Trekkies get involved as well as insult comic Jeffrey Ross.

Blake's brother shows up at the hospital, and he needs something. Owen thinks something is suspicious about Rideworld.

Owen wants to have sex with Lola, but he thinks she is a ghost so he asks Dr. Flame to stop his heart to send him to the spirit world to find her. The hospital takes in overflow patients dressed in sexy costumes on Halloween while Chet shows Chief his sexy costume.

Lola is back, but everyone thinks she is a ghost. Cat goes into labor just as Nicky slips away. Dr. Valerie Flame joins the staff.

The hospital gets a new administrator, Sy Mittleman, who everyone but the Chief despises. Cat struggles with the loss of Lola, her pregnancy, and her feelings for Nicky. Glenn accidentally discovers the cure for cancer.