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Charlie puts on a rock opera based on his song "Nightman," and he gets the rest of the gang to help him.
The gang give an extreme home makeover to an ill-fated family, and they hope to receive good karma in return so that their own dreams will come true.
The gang fudge history by claiming that Paddy's Pub was responsible for cracking the Liberty Bell in an attempt to turn their dive into a Philadelphia landmark.
After Dee suffers a heart attack, she and Dennis try to live a healthier lifestyle. Meanwhile, Charlie and Mac take corporate jobs to get health insurance.
Mac and Frank find Dennis' erotic memoir and attempt to profit from it, while Dee and Charlie spend a day in each other's shoes.
A newspaper columnist calls Paddy's the worst bar in Philadelphia, and the gang kidnaps him in an effort to force him to change his mind.
Frank and Charlie find that someone has soiled their bed, and Mac and Dennis join them as they attempt to catch the culprit. Meanwhile, Dee leads Artemis and the waitress on a "Sex and the City"-style night on the town.
Frank, Dee and Dennis find unique ways of dealing with the loss of Mac and Charlie. The guys faked their deaths to avoid Mac's vengeance-obsessed father, who was released from prison.
After Mac's revenge-obsessed father is released from prison, Mac and Charlie fake their deaths to save their lives. Frank, Dee and Dennis find unique ways of dealing with the loss of the guys.
Charlie wants Mac to beat up the waitress's unknown new boyfriend. Trouble is, Mac is the boyfriend.
Mac and Frank judge a contest to determine Paddy's next top model; Dee and Charlie strive to come up with YouTube's next sensation.
Mac, Dennis, and Charlie take advantage of high gas prices by investing in barrels of gasoline and selling them door-to-door; Dee and Frank plot to brand Bruce Mathis as a terrorist leader when they find out that he plans to give their money to a Muslim community center.
Dee and Charlie eat some of Frank's stash of extraordinarily tasty meat and won't rest until they can get more. Meanwhile, Mac and Dennis take sport hunting to the next level.
In Season 16, it's a challenge for Ronald "Mac" MacDonald, Charlie Kelly, Dennis Reynolds, Dee Reynolds, and Frank Reynolds who yearn for the past as they attempt to survive in 2023. This year alone, Mac battles with allergies and long-distance dating, Charlie takes on his long-forgotten sisters, Dee fights for rent control and women's athletics, Frank wrestles for his gun, and Dennis struggles to improve his mental health. At the end of the day, they're navigating 2023 with 16 years of baggage as a few figures from their past rear their heads.
