After a national casting call that received over nine thousand submissions, Henry Louis Gates, Jr. meets 3 everyday Americans. Each has a family mystery that they have spent years trying to solve—only to reach dead ends. Using genetic genealogy and old-fashioned detective work, Gates unravels these mysteries, allowing each of his guests to understand themselves—and their families--as never before.

Henry Louis Gates, Jr. explores the roots of actor Michael Douglas & writer-director Lena Dunham. Both guests are the children of famous artists—and both proudly followed in their parents' footsteps. But their family trees contain a cast of characters whose lives were forgotten. Gates recovers them, telling fascinating stories from the shtetls of Eastern Europe to the streets of colonial America.

Henry Louis Gates, Jr. maps the family trees of comedian Tracy Morgan & actor Anthony Ramos—two native New Yorkers whose roots stretch to surprising places and contain inspiring stories. Moving from the Canary Islands to battlefields in Europe & Asia to slave plantations in Virginia, long-lost records reveal ancestors who laid the groundwork for Tracy and Anthony's success by fighting to survive.

Henry Louis Gates, Jr. helps musician Dionne Warwick & actor Danielle Brooks break down barriers imposed by the slave system to learn the names of their ancestors who endured unimaginable ordeals—but emerged to forge families that thrived.

Henry Louis Gates, Jr. explores the roots of journalist Sunny Hostin & actor Jesse Williams—revealing the tremendous diversity hidden within their family trees. Sifting through stories of Swedish musical prodigies, Spanish slave traders, Southern plantations, and Salem Witch Trials, Gates unravels deep secrets and uncovers lost ancestors—compelling each of his guests to rethink their identities.

Henry Louis Gates, Jr. uncovers the roots of comedians Bob Odenkirk and Iliza Shlesinger—two very funny people whose family trees brim with stories that are more drama than comedy. Moving from Napoleonic France to Nazi-occupied Poland to the castle of a European duke, Gates introduces them to relatives who took great risks and overcame enormous hardships for the sake of their families.

Henry Louis Gates, Jr. helps singer Sammy Hagar and actor Ed O'Neill uncover their hidden roots, revealing scandals and secrets that their ancestors went to great lengths to conceal. Traveling from criminal underworlds to Civil War battlefields, they explore the meaning of family bonds—meet heroes and villains—and celebrate the virtue of accepting one's relatives, whoever they may be.

Henry Louis Gates, Jr. meets actors LeVar Burton and Wes Studi—two men who grew up without their fathers, haunted by questions about entire branches of their family trees. With only a handful of clues to guide him, Gates uncovers stories his guests have long wanted to hear, introducing them to ancestors whose names they've never known-—and revealing their connections to key moments in history.

Henry Louis Gates, Jr. meets Valerie Bertinelli and Brendan Fraser—two actors who found fame when they were young and lived their lives in the limelight, cut off from their roots. Each discovers ancestors who paved the way for their success.

Henry Louis Gates, Jr. explores the remarkable roots of singers Alanis Morissette and Ciara, using DNA analysis and genealogical detective work to travel back centuries, revealing his guest's hidden connections to history—and to music.