After a child in a day-care center dies from an antibiotic resistant bacteria, Briscoe and Curtis try to find the source of the infection, leading to a case involving an extramarital affair, embezzlement and a drug manufacturer.

NYPD Detective Mike Logan, who was reassigned to Staten Island after punching a corrupt politician, takes on a grisly murder case. When the investigation leads him back to the 27th Precinct, Logan sees a chance to resurrect his flailing career and be reinstated as a homicide detective.