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After a child in a day-care center dies from an antibiotic resistant bacteria, Briscoe and Curtis try to find the source of the infection, leading to a case involving an extramarital affair, embezzlement and a drug manufacturer.
The investigation into how a teen got wounded leads to a case involving a young woman's murder and a drug operation.
After the detectives find a murdered postman and a woman who was left for dead in her apartment, the investigation leads to a serial killer and a surprise.