The present day on Egghead, Bonney is caught in St. Saturn's grasp, knowing he is responsible for her father's transformation into a cyborg. However, Saturn reveals an even more shocking truth that throws Bonney into despair.

Bonney sails out to sea in search of her father and rises to prominence. At the same time, Luffy makes his name by defeating the Arlong Pirates and declaring war against the World Government. Watching his actions, Kuma begins to hold a certain belief.

Bonney has been waiting for a letter from her father Kuma who promised to write to her. But with no letters in sight, she turns nine and one day realizes her disease is cured. She then decides to go out to sea to search for her father.

Taking advantage of Kuma's love for his daughter Bonney, the World Government imposes three harsh conditions on him in exchange for her treatment. Kuma agrees to them and Bonney's treatment starts at Laboratory 8 in tandem with the clone development with which Kuma agrees to cooperate.

Chopper and Carrot review the history of Kizaru, Sentomaru, and Vegapunk. They talk about how good friends the three of them once were, how they came to be at odds due to their individual circumstances, and the fierce fight they got into at Egghead.

By fighting off King Bekori who is supported by the World Government, Kuma is put on the wanted list and decides to travel around the world in search of a cure for Bonney's disease. He reunites with Dragon and learns about the Government's eccentric scientist who might be able to cure Bonney.

Two years after Ginny's abduction, the Revolutionary Army suddenly receives a call from her.

Kuma and Ginny live peacefully in the Sorbet Kingdom eight years after the God Valley Incident. However, their new king initiates a policy of enslaving the poor. Kuma tries to free those who were captured but ends up being imprisoned himself. But a familiar face comes to rescue him.

The human hunt begins and the Celestial Dragons start chasing locals of God Valley and slaves for prizes. Ivankov and Ginny share with Kuma and the others their surprising plan to survive the game. Meanwhile, ships full of infamous pirates start arriving on the island one after another.

Bonney gets captured by St. Saturn, whose enigmatic power keeps Sanji and Franky from saving her. In St. Saturn's clenched fist, she recalls the memories of her father, Kuma. 47 years ago, Kuma was born to a father of a race on the verge of extinction.

Chopper and Carrot review the history of Bartholomew Kuma and Bonney. They talk about how they were involved with the Straw Hats in the past, the special bond between them, and the commotion they are now creating at Mary Geoise and Egghead.

Vegapunk successfully wrests back the Pacifistas from the Navy, but another party soon gains control of them. At the same time, Luffy, Zoro, and the others sense an unearthly presence just as a pentagram suddenly appears on Egghead.

A bizarre battle between Luffy and Kizaru heats up. Meanwhile, in the Fabiriophase, Bonney is all alone and being chased by the Navy soldiers. Dr. Vegapunk sees this and can't help but leave the Labophase to rescue her, risking his life.

Kuma finally reaches Mary Geoise and keeps advancing even without free will or mind. But Fleet Admiral Akainu stands in his way. On Egghead, Kizaru enters the Labophase and delivers a powerful kick to Luffy who tries to stop him.

Navy Admiral Kizaru finally makes landfall on Egghead and Sentomaru, Vegapunk's bodyguard, stands in his way. The two men who were once close now clash violently. Meanwhile, Luffy and the others try their best to move the Sunny to the back side of the island to escape.

In the Labophase on Egghead, which is completely surrounded by the Navy, Luffy and the others devise a plan to escape the island. However, the Frontier Dome, the laser defense system, cannot be deactivated without York's secret passcode.

As the news about Garp's disappearance and Luffy's hostage situation spreads, a mysterious earthquake suddenly shakes the entire world. Meanwhile, a huge Navy fleet led by Admiral Kizaru surrounds Egghead and listens in as York contacts Mary Geoise to negotiate a deal.