Dr. Manning returns from maternity leave and helps treat a teen with a long history of medical issues. Dr. Choi attends to a former Navy shipmate with a potentially life-threatening ailment and goes above and beyond the scope of his duties to ensure he gets the proper treatment. Saudi Prince Faisal arrives at the hospital for a planned surgical procedure, but only from Dr. David Downey, the hot-shot surgeon who takes a shine to the work of Dr. Rhodes. Meanwhile, a budding romance between Sarah and hospital lab tech Joey looks hopeful, but April might think otherwise.

Dr. Rhodes and Dr. Downey make plans to operate on Ray, a 9/11 hero who is suffering from pulmonary fibrosis. A new set of lungs could save his life through an innovative surgical procedure but an unforeseen medical problem arises with Ray that might derail the doctor's grand plans. Sarah contemplates which hospital to select for her residency match while Maggie and April make their push for her to remain at Chicago Med. Meanwhile, Dr. Choi works to determine the cause of an injured teenage star hockey player with an overbearing father while Dr. Halstead and Dr. Manning continue to clash.