When legal issues complicate matters that stall a life-saving bone marrow transplant, Sharon Goodwin must decide whether to disobey direct orders or stand by and put a patient's life in jeopardy. April tends to a caring, homeless man who Dr. Charles evaluates, only to come to an unusual diagnosis that explains his recent behavior. Dr. Natalie Manning's parents come to town to see their new grandchild, much to the dismay of her mother-in-law, Helen. Dr. Connor Rhodes treats a couple who are injured on their first date by a hit-and-run driver, who Dr. Halstead discovers has his own reasons for causing the accident.

Dr. Halstead revives a "do-not-resuscitate" terminally ill cancer patient, and the repercussions prompt his quick removal from the case and a pending lawsuit against Chicago Med. A homeless man's arrival is passed down to April and an uneager Dr. Reese, but the circumstances surrounding his short stay catch both off-guard. Following the assessment and treatment of a bi-polar patient with an unhealthy dependence for lithium, Dr. Choi's own personal issues come to the surface, prompting him to seek the advice of Dr. Charles. The medical staff is shocked to learn one of their own has life-threatening disease.