Two airplane stowaways are brought into the hospital after suffering major injuries from the travel, prompting Sharon Goodwin to receive a visit from the Department of Homeland Security regarding the undocumented immigrants. Cornelius Rhodes, the wealthy father of Dr. Connor Rhodes, is honored after making a big donation to the hospital for a new psych ward, forcing dark family secrets to the surface. Dr. Natalie Manning's big day arrives and Dr. Will Halstead's good intentions to help are misconstrued by her mother-in-law, Helen. Meanwhile, Dr. Sarah Reese asks Dr. Charles for advice on how to deliver heartbreaking news to a young boy while also warning his family about the possibility that their other son may also have the same life-threatening disease.

Dr. Manning returns from maternity leave and helps treat a teen with a long history of medical issues. Dr. Choi attends to a former Navy shipmate with a potentially life-threatening ailment and goes above and beyond the scope of his duties to ensure he gets the proper treatment. Saudi Prince Faisal arrives at the hospital for a planned surgical procedure, but only from Dr. David Downey, the hot-shot surgeon who takes a shine to the work of Dr. Rhodes. Meanwhile, a budding romance between Sarah and hospital lab tech Joey looks hopeful, but April might think otherwise.