Guy attempts to put his own stamp on Holby by hiring former colleague Colette Sheward as Director of Nursing. His clean break does not last long however when he is confronted by a case from his past. Jonny tries to lighten Jac's work load but can he keep across the extra cases? Serena faces a tough task impressing Guy when a particularly difficult patient arrives on AAU.

Fed up following his recent heartbreak Michael breaks all the rules to perform a transplant operation for a desperate father and his son. When Guy confronts him about it he walks away from Holby after being suspended. Under pressure from her sons father Gemma makes a crucial mistake with a patient and decides to quit to focus on her son. Edward continues to sideline Mary-Claire and blames her when a machine malfunctions.