Under pressure from Raf, Harry desperately tries to find his speciality when he stumbles across a bariatric patient. On the day of Emma's christening Jac is left with a difficult choice when a patient with a rare heart condition arrives at Holby.

Arthur is undermined by Dominic when they treat a patient with a mystery illness leading to a near fatal situation. Harry's father is admitted to Holby leading Serena to create an opportunity to impress Guy. When Jonny is cut out of the loop by Jac he teams up with Bonnie to make his voice heard.

New registrar Raf Di Lucca arrives on AAU and makes an impression when he takes on a revolutionary procedure. Sacha comes under pressure from Guy to help Zosia make it as a surgeon and Jac struggles to bond with Emma.

Jonny is shocked when Jac prioritises her patients over her daughter on the day of her big operation. Arthur attempts to sabotage Dominic in a bid to get him thrown out of Holby. Meanwhile Mo and Adele clash when Mo pulls rank when they deal with a difficult patient.

There is shock on Keller when doctor Dominic Copeland returns to Holby to retake his first year. Will Arthur forgive him for what he did to Malick? Mo's sister Adele joins AAU as the new healthcare assisstant but will there be trouble between them? Meanwhile Colette discovers Guy cut corners to give her the nursing job and now she must prove herself to somebody from HR.

When Jac goes into labour early everyone hopes that the baby will be alright. Meanwhile Ric goes to a school reunion and meets an old flame. Has he left it too late?

When Guy continues to clash with Zosia he accepts their relationship is purely professional but is that what she really wants? Meanwhile on AAU both Serena and Mary-Claire face the difficult task of picking themselves up after being fooled by Edward.

When Mary-Claire stands up to Edward and exposes him for the alcoholic bully he is can she persuade Serena to believe her. With Elliot still reeling from Zosia's revelation that Guy is her father she is determined she won't allow him back into her life following the death of her mother. But will a present from beyond the grave make her change her mind?

Fed up following his recent heartbreak Michael breaks all the rules to perform a transplant operation for a desperate father and his son. When Guy confronts him about it he walks away from Holby after being suspended. Under pressure from her sons father Gemma makes a crucial mistake with a patient and decides to quit to focus on her son. Edward continues to sideline Mary-Claire and blames her when a machine malfunctions.

Edward turns nasty with Mary-Claire when she threatens to reveal their affair to Serena. Guy press-gangs Elliot into performing the Herzig operation on a patient but when it doesn't go well he is left questioning his ethics. Zosia uses Arthur's obsession with Chantelle to earn herself the spare room in his flat.

Guy attempts to put his own stamp on Holby by hiring former colleague Colette Sheward as Director of Nursing. His clean break does not last long however when he is confronted by a case from his past. Jonny tries to lighten Jac's work load but can he keep across the extra cases? Serena faces a tough task impressing Guy when a particularly difficult patient arrives on AAU.

Serena has her hands full when a major incident takes place but is later shocked to discover the new CEO, Guy Self, has arrived without her knowledge. Will they get off on the right foot? Malick is furious when he discovers Jake is working at Holby again but when a particular case takes them both to the edge he realises he must make a clean break away from Holby.

When Chrissie is offered the job of Director of Nursing it forces her to take stock of her life at Holby and comes to the decision to leave her past behind and make a clean break elsewhere. Meanwhile Digby struggles to manage an increasingly erratic Malick but will he be able to stand up to his mentor?

Chantelle faces her biggest fear when Cameron is again admitted onto the ward. When Digby confronts her with his true feelings she realises things have gone too far between them and she must leave to put it right. Mo is shocked to see her online date turn up at the hospital with chest pains. When Sacha serves Chrissie with divorce papers she turns to Michael for comfort.

Malick feels as redundant as ever when his former mentor is booked into the hospital as a patient. Despite his injury it does not take long for him to start interfering on the case. Despite having booked the chapel for the vow renewal Sacha and Chrissie question if they have the commitment to make another go of things.

Chantelle faces her first day back at work after the crash. Despite looking forward to the comfort of her job she discovers her expectations were not all they were cracked up to be. Elliot has more trouble with Zosia when she interferes in one of his cases.

Harry has a difficult day when a childhood friend is admitted with a serious condition. Gemma brings her son to work once again but when he and medical drugs go missing she has to face the consequences with Ric. Meanwhile after clearing the air with Sacha, Mo tries to hide the fact she is online dating.

Malick struggles to come to terms with the fact he is now a patient and that his career may now be over. Elliot struggles to manage new mentee Zosia when she starts carrying out psyche assessments on his patients and Sacha struggles to come clean to Chrissie about his kiss with Mo.