When Chrissie is offered the job of Director of Nursing it forces her to take stock of her life at Holby and comes to the decision to leave her past behind and make a clean break elsewhere. Meanwhile Digby struggles to manage an increasingly erratic Malick but will he be able to stand up to his mentor?

Guy attempts to put his own stamp on Holby by hiring former colleague Colette Sheward as Director of Nursing. His clean break does not last long however when he is confronted by a case from his past. Jonny tries to lighten Jac's work load but can he keep across the extra cases? Serena faces a tough task impressing Guy when a particularly difficult patient arrives on AAU.