Struggling with the news that Dominic is her half-brother, Chloe is forced to operate with him. Lofty returns to Holby with a secret.

As Dominic continues to treat Isaac's father, Lofty is determined to protect him, but when Dominic refuses to let him it puts their marriage in doubt and plays into Isaac's hands. A hungover Jac is mortified she can't remember how the previous night ended with Ken, much to Kian's amusement. She eventually gets her answer, but not before having to save Ken's life first.