Danny Shaughnessy goes ahead with his wedding to Marija Ovcar, despite his mother Kath being sure it's a big mistake. Sandy Harper wangles herself the role of bridesmaid. Meanwhile, a young patient of Keri McGrath's is discovered to have had a recurrence of her cancer, while her parents argue because of their different views on religion. A woman comes into Darwin Ward with apparent appendicitis, that under surgery is found to be an infection caused by a swab left behind after a previous operation.

Tragedy strikes when Steve Waring leaves his son to look after his sick mother. On Darwin Ward, a blind man regains his sight after a relatively minor procedure on his lungs, and a cantankerous young homeless man causes problems for Simon Shaughnessy on his first day at work at Holby City, assisting Stan Ashleigh. A heart patient whose son appears not to want the burden of caring for him prompts a spat between Alex Adams & Samantha Kennedy, leading them to explore their personal experiences of caring for their fathers.