On New Year's Eve, Sophie, an ex-girlfriend of Alex Adams, arrives at Holby City, bringing with her a daughter he was completely unaware of. A strong-willed 77-year old, Annie Hackett, coerces Ric Griffin into doing an operation to remove part of her colon, against his advice. Simon Shaughnessy gets very drunk while still on duty, and has to be escorted off the premises by his family. Kath Shaughnessy's suspicions about Chrissie Williams and Alistair Taylor are as good as confirmed.

Just before Christmas on Keller Ward, David Thomas, a young rugby player is brought in having sustained a bad leg fracture. Sandy Harper takes a fancy to him and stays late to decorate his bedside with extra tinsel. He dies during the night from complications from an unsuspected head injury. Chrissie Williams has to tell Alistair Taylor repeatedly that their affair is over. Janice Taylor finds out that she is pregnant again, but finds Chrissie's badge under the marital bed and sees husband Alistair behaving suspiciously with Chrissie. She confronts him, but he denies it sufficiently convincingly.

Chrissie Williams wakes up with Alistair Taylor in the Taylors' bed. Steve Waring's son is increasingly upset over his mother's death, and skips school to binge drink at home, causing Steve to have a stressful time sorting him out. On the wards, a young man is admitted with acute pancreatitis, but Tash Bandara's sympathy is more limited than the man's father's. A long-distance lorry-driver patient with a heart problem is visited by two women who each think that she is his wife. Marija has to have it pointed out to her than Danny actually fancies her.

Tragedy strikes when Steve Waring leaves his son to look after his sick mother. On Darwin Ward, a blind man regains his sight after a relatively minor procedure on his lungs, and a cantankerous young homeless man causes problems for Simon Shaughnessy on his first day at work at Holby City, assisting Stan Ashleigh. A heart patient whose son appears not to want the burden of caring for him prompts a spat between Alex Adams & Samantha Kennedy, leading them to explore their personal experiences of caring for their fathers.

Owen Davis confronts Alistair Taylor about his growing relationship with Chrissie Williams, but he claims nothing is going on. A young woman is brought in suffering from advanced liver disease. A woman prisoner is also on the ward, who, when she is fully diagnosed, wants to do something that Ric Griffin is sure will give the medical ethics board a tough decision.

Danny Shaughnessy goes ahead with his wedding to Marija Ovcar, despite his mother Kath being sure it's a big mistake. Sandy Harper wangles herself the role of bridesmaid. Meanwhile, a young patient of Keri McGrath's is discovered to have had a recurrence of her cancer, while her parents argue because of their different views on religion. A woman comes into Darwin Ward with apparent appendicitis, that under surgery is found to be an infection caused by a swab left behind after a previous operation.

Janice Taylor wants to proceed with another round of IVF treatment immediately, but Alistair is not so sure. Chrissie Williams offers him a shoulder to cry on over a drink, but it leads to somewhat more. Samantha Kennedy gets badly involved with an anorexic heart patient and her over-protective mother. Janice has to tell Danny Shaughnessy not to take too much pity on a struggling single mother, but he is also becoming increasingly involved with Marija's attempt to evade the authorities.

Janice Taylor endangers her unborn baby, and Tash Bandara's attempts to save a patients life are met with hostility.

Keri McGrath's rape is investigated by a tribunal. Darwin Ward is troubled by a manic depressive heart patient. Marjica Ovcar has to bring Luka back for an emergency treatment, even though she cannot pay for the treatment she has already.

Janice Taylor holds a dinner party to welcome Anton Meyer back to work, his first case badk is a heart transplant patient who has been poorly treated by the system. Janice discovers she is now pregnant to to the latest round of IVF. Alex Adams is jealous when he finds Samantha Kenedy and Ric Griffin together. Word begins to spread about Keri McGrath and Liam Evans.

Keri McGrath is traumitised after her evening with Liam. A father learns of his daughters condition following the removal of a blockage from her airways. An obese patient refuses an appendectomy. Janice Taylor has another session of IVF.

Anton Meyer proves not to be the ideal patient and his recovery suffers a minor setback. Alex Adams and Alistair Taylor have a clash of personalities. Keri McGrath finds herself in a compromising position with Liam Evans after Sandy Harper's 20th birthday party.

Anton Meyer is seriously injured in a road-rage incident and is brought to Holby for an emergency operation. Mike Barratt's replacement Ric Griffin arrives. Alex Adams plays detective when he realises that the wife of an apparent road injury victim admitted at the same time is driving around in Meyer's car.