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DIY SOS and Children in Need join forces to transform The Joshua Tree, a children's cancer support charity, in an emotional and ambitious special build.
In south London, Nick and the team help five siblings who recently lost their mum. The two oldest, Somer and Samuel, are doing their best, but the family is struggling in a cramped home.
Eight-year-old Rafi was left with brain damage after falling seriously ill. Now he is home after a year in hospital, but his house isn't suitable - the family needs the team's help.
In south Wales, Nick and the team help Dan and Anna after a freak accident. Now a wheelchair user, Dan needs his home transformed to support his rehab and his goal to walk again.
The team are in Leicester to help seven-year-old Isla, who longs for independence. Everything must be made bespoke, and fitting it all in will be a huge challenge.